Tuesday, October 8, 2013

ACTH producing adenoma(ACTH製造腺瘤)/Cushing's disease(庫欣病)

症狀/併發症(symptom/complication)
@obesity: 97%
@cutaneous atrophy: 76%
@hypertension: 75%
@gonadal dysfunction
@moon face: 89%
@osteopenia
@glucose intolerance: 70%
@proximal muscles weakness
@hirsutism多毛症
@psychiatric smptoms

資料來源:physio-pedia
@ectopic ACTH syndrome may effect nail
病因(etiology)

檢查/準則(examination/criteria)
#Dexamethasone suppression test: test from low dose to high dose, high dose will suppress
#Inferior petrosal sinus sampling of ACTH: check is right or left adrenal gland, Sensitivity:97% Specificity:100%

資料來源:health-7
#late night salivary cortisol
#胰島素耐受性試驗(Insulin tolerance test, ITT)
治療(treatment)
$Transsphenoidal microsurgery
$Radiotherapy
drug
$Ketoconazole: Inhibitors of adrenal steroidogensis
$Mitotane: Inhibitors of adrenal steroidogensis
鑑別診斷(Differential Diagnosis)

流行病學(Epidemiology)
+more common in children than adults
+secondary functional pituitary tumor
看更多see more:疾病(disease)HomeAny source

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