Autoimmune Polyglandular Syndromes, APS(多腺體型自免疫症候群)

症狀/併發症(symptom/complication)	@type I @@Mucocutaneous Candidasis: easily infection, 73~100% @@Chronic Active Hepatitis @@Malabsorption @@Oral Squamous Cell Carcinoma @@Alopecia @@Vitiligo @@Nail Dystrophy @@pernicious anemia @@gonadal failure:30~60% @@hypoparathyroidism(副甲狀腺機能低下):77~89% @@primary adrenocortical insufficiency(原發性腎上腺皮質機能低下症)=Addison's disease :60~86% @type II @@primary adrenocortical insufficiency(原發性腎上腺皮質機能低下症)=Addison's disease:70~100% @@type I diabetes mellitus(第一型糖尿病):41~52% @@Autoimmune adrenal insufficiency @@Type 1 DM @@Celiac Disease @@Dermatitis Herpetiformis @@Alopecia @@Vitiligo: 20～40％ combined with thyroid and digestive problem @@idiopathic thrombocytopenic purpura @@Serositis(漿膜炎)
病因(etiology)	|hypofunction of endocrine organs except Graves' disease/Exophthalmic Goitre(突眼性甲狀腺腫) |sometimes can detect antibodies but be asymptomatic |genetics ||type I: Autosomal recessive,AIRE 21 chromosome ||type II: Polygenic, HLA DQ2 and DQ8 HLA DRB1*0404
檢查/準則(examination/criteria)
治療(treatment)
鑑別診斷(Differential Diagnosis)
流行病學(Epidemiology)	+type I: baby is comon, all cases fall ill before 30 years old +type II: from children to adults

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