Sunday, October 27, 2013

Dyslipidemia(血脂異常症)

症狀/併發症(symptom/complication)

病因(etiology)
type

Phenotype
I
IIa
IIb
III
IV
V
Elevated Lipoprotein
Chylomicron
LDL
LDL and VLDL
IDL
VLDL
VLDL and chylomicrons
|genetic
||type IIa=familial hypercholesterol: LDL receptor defect, LDL can not into peripheral tissue
||familial combined hyperlipidemia: apoB100 hyperproduction
||type III hyperlipidemia: presence of ApoE E2/E2 genotype, It is due to cholesterol-rich VLDL (β-VLDL). Its prevalence has been estimated to be approximately 1 in 10,000
檢查/準則(examination/criteria)
#total cholesterol (TC)> 200 mg / dL
#low-density lipoprotein cholesterol, LDL-C> 130 mg / dL
#high-density lipoprotein, HDL-C <40 mg / dL
#triglyceride, TG> 150 mg / dL
治療(treatment)
$type IIa (which has hyperLDL) can use statin drugs
$type IIb, III, IV, V (which has VLDL and derivation)can use fibrates
$type I (which has chylomicron) do not have any drug to treat
鑑別診斷(Differential Diagnosis)

流行病學(Epidemiology)


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