Wednesday, October 30, 2013

HMG-CoA reductase inhibitors

商品名(trade name)
Lovastatin (Mevacor)
Pravastatin (Pravachol)
Simvastatin (Zocor)
Fluvastatin (Lescol)
Atorvastatin (Lipitor)
Rosuvastatin (Crestor)
藥理作用(Pharmacological Effects)
資料來源:accesspharmacy
[inhibit HMG-CoA reductase, and no cholesterol synthesis
[a kind of compete inhibitor
other function
[stimulate DNA expression to produce more LDL receptor, increase LDL resorption from blood
[low cholesterol decrease VLDL secretion to blood

資料來源:health-7
[Extracted from Monascus rice
用量與用法(Dosage and Usage)
usage
]statins is a kind of prodrug, need liver metabolism can be effect, therefore, oral is better than intravenous
適應症(Indications)

副作用(Side effect)
}muscle pain
}myolitis
}hepatic toxicity
禁忌/交互作用(Contraindications / interaction)


看更多see more藥理學(pharmacology)
HomeAny source

No comments:

Post a Comment