Hyperaldosteronism(醛固酮過多)=Conn syndrome

症狀/併發症(symptom/complication)	3H @Hypernatremia @hypokalemia:  function of aldosterone is sodium retention, discharge of potassium @hypertension with left ventrical hypertrophy, due to too extracellular fluid volume @increased reabsorption of sodium will cause water retention @Low potassium can affect the heart muscle function and neurological problems such as @weakness, @numbness, @weakness, @tonic contraction, @visual disturbances, @sweating complication @diabetes mellitus @weight gain @usually monolateral @proteinuria: hypertension is a reason @Increases tubular hydrogen ion secretion and @mild alkalosis
病因(etiology)	|Zona glomerulosa tissue abnormal |primary hyperaldosteronism: #plasma renin is low ||secret too much aldosterone |secondary hyperaldosteronism (this is not Conn syndrome): #plasma renin is high a physiological mechanism in order to increase body blood volume ||Renal blood flow deficiency ||low blood volume ||water species and ||pregnancy pathology |Aldosterone-producing adenoma, APA 35% |Idiopathic hyperaldosteronism, IHA 60% |Adrenocortical carcinoma <1% |Glucocorticoid-remediable aldosteronism, GRA |function loss of sodium retention, discharge of potassium
檢查/準則(examination/criteria)	#screen test ##Plasma aldosterone (PA) / plasma renin activity (PRA) > 30 : renin will stimulate aldosterone production, therefore, high aldosterone will inhibit renin secretion-->90% sensitivity, 91% specificity #confirm test ##鈉負荷試驗(Sodium loading test) ##Captopril test: Captopril 50 mg and wait 90 minutes to detect plasma aldosterone, if >15ng/dl that is positive ##intravenous saline infusion test ##fludrocortisone suppression test
治療(treatment)
鑑別診斷(Differential Diagnosis)
流行病學(Epidemiology)	+female:male=2:1 +30~50 years old

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