Sunday, October 13, 2013

osteoporosis(骨質疏鬆症)

症狀/併發症(symptom/complication)
@ low bone mass
@microarchitectural deterioration
@increase in fracture risk 
病因(etiology)
class
|primary osteoporosis
||decrease bone mass in postmenopausal women (postmenopausal osteoporosis)
||older men and women (senile osteoporosis)
|secondary osteoporosis
||loss of bone mass resulted from other clinical disorder
檢查/準則(examination/criteria)
#vertebrae is the most incidence rate of body, but sometimes influenced by arteriosclerosis
#T score: BMD is compared with 25-year-old Caucasian women
##Normal: T scores fall less than -1 SD
##Osteopenia: T score fall between -1 and -2.5 SD
##Osteoporosis: T score fall more than -2.5 SD
治療(treatment)
$Non-pharmacologic
$$do exercise
$$Maintain nutrition status
$$Prevention from trauma
$Medication
$$Anti-resorptive agent: do not improve calcium absorption, but block bone loss
$$$Calcium: 1500 mg/day (Milk contain about 1 mg calcium /ml)
$$$Vitamin D: 400 - 800 IU/D with adequate calcium intake
$$$Estrogen
$$$Selective Estrogen Response Modulators, SERMs
參見:藥理學(pharmacology)
$$$Bisphosphonates: inhibit osteoclast
$$Bone formation agent
鑑別診斷(Differential Diagnosis)

流行病學(Epidemiology)


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