Tuesday, October 8, 2013

pituitary adenoma(腦下垂體腺瘤)

症狀/併發症(symptom/complication)
@pressure of the optic chiasm cause bitemporal hemianopia
typing
@@eosinophilic adenoma: acromegaly and gigantism
@@basophilic adenoma: Cushing syndrome
@most of pituitary adenoma is single cell type: monomorphism

資料來源:studyblue
@pituitary adenoma has lots of capillary
@Headache
gross

資料來源:safetyca
病因(etiology)
|most of pituitary adenoma is functional tumor
typing
||prolactin producing adenoma(泌乳激素製造腺瘤): 60%
||growth hormone adenoma(生長激素腺瘤): 20%
||ACTH producing adenoma(ACTH製造腺瘤): 10%
||Gonadotroph cell adenoma
||Thyrotroph cell adenoma
||Plurihormonal pituitary adenoma
||Non functional tumor: 10%
|||thyrotropin-producing adenoma: rare
|||gonadotropin-producing adenoma: rare
|Slow-growing neoplasm
檢查/準則(examination/criteria)
for pituitary adenoma
#Ki-67 index <3%
#if Ki-67 index >3%, most of cases are carcinoma (must show metastasis); without metastasis-->atypical adenoma; metastatsis carcinima
#abundant capillary

資料來源:pathpedia
治療(treatment)
$craniotomy, is directed through the skull above the eye
$transsphenoidal operation, is directed through the nose

資料來源:neurosurgery
$bromocriptine: This drug will most often cause a reduction in the size of the tumor and at the same time cause a decrease in an abnormally high prolactin level in the blood. Although Bromocriptine may control the tumor, it may not cure it. Treatment with Bromocriptine must often be continued for many years at reduced levels
鑑別診斷(Differential Diagnosis)

流行病學(Epidemiology)
+the most common pituitary tumor
+10~15 % of intracranial neoplasm
+90% of pituitary tumor
+prolactin producing adenoma(泌乳激素製造腺瘤) is the most common type
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