primary adrenocortical insufficiency(原發性腎上腺皮質機能低下症)=Addison's disease

症狀/併發症(symptom/complication)	3H @Hypoglycemia @Hyponatremia @Hypotension @weakness @easy fatigue @fever @GI disturbances: nausea and vomitting @decreased blood pressure @dehydration @poor appetite @weight loss @hyperpigmentation: due to high ACTH @poor ability to fight infections @Amenorrhea @Insidious onset 資料來源：studyblue
病因(etiology)	|Adrenal gland is damaged itself-->aldosterone secreting insufficiency |adrenal gland atrophy |Autoimmune adrenocortical insufficiency: antibody attack adrenal cortex itself |infection: Histoplasmosis, coccidioidomycosis,cryptococcosis, HIV, CMV |Adrenal hemorrhage: Clotting factor or vascular disease |Adrenoleukodystrophy, ALD(腎上腺腦白質失養症) |Congenital adrenal hyperplasia(先天性腎上腺皮質增生症) |Infiltration disorder: Copper ion, iron ion Deposit 參見：Adrenocortical insufficiency(腎上腺皮質機能低下症) class |mineralcorticoid deficiency ||decreased extracellular fluid volume |glucocorticoid deficiency ||impossible to maintain normal blood ||iglucose concentration in blood decreases ||imelanin pigmentation: ACTH melanin ||vitiligo
檢查/準則(examination/criteria)	# K↑, Na↓, BP↓, hyperpigmentation. #eosinophilia #ACTH刺激試驗(ACTH stimulation test)
治療(treatment)	$mineralocorticoid: 0.05–0.1 mg per day PO $glucocorticoid: 20–30 mg/d (with meals) $ Replacement therapy for secondary or tertiary adrenocortical insufficiency: ACTH
鑑別診斷(Differential Diagnosis)
流行病學(Epidemiology)

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