症狀/併發症(symptom/complication) | gross @hurthle cell will let thyroid look brown @goiter @lymphocytic infiltration of thyroid gland @Hypothyroidism(甲狀腺機能低下) |
病因(etiology) | |autoimmune disease: T lymphocyte attack follicular cell |chronic autoimmune thyroiditis |genetic: HLA subtype |antibody attack: anti-TSH antibodies, antithyroglobulin, antithyroid peroxidase antibodies |
檢查/準則(examination/criteria) | histology #hurthle cell: enlarged epithelial cells with abundant eosinophilic granular cytoplasm as a result of altered mitochondria  資料來源：日內瓦的醫學教育和研究基金會 #lymphocyte gathers and looks like germinal center  資料來源：pathologystudent gross #yellow #Homogeneous  資料來源：薩卡特卡斯州自治大學 #thyroid ultrasound: looks like Graves' disease/Exophthalmic Goitre(突眼性甲狀腺腫), but only low blood flow #fine-needle aspiration cytology, FNAC: exclude Graves' disease/Exophthalmic Goitre(突眼性甲狀腺腫) #thyroid ultrasound: Diffusely enlarged thyroid gland, marked hyperemia  資料來源：ultrasound-images |
治療(treatment) | $thyroxine and its analogue $$1.6 mcg/kg body weight per day, but dose range dose is wide $$start with full dose, but elder start at low dose $$dose need to increase: pregnancy, weight gain, estrogen therapy |
鑑別診斷(Differential Diagnosis) | |
流行病學(Epidemiology) | +Most common cause of hypothyroidism +10% patients of Hypothyroidism(甲狀腺機能低下) +female: male: 10~20:1 +age 45~65 years old |
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