Tuesday, November 12, 2013

hypertension(高血壓)

症狀/併發症(symptom/complication)

病因(etiology)
definition
|normal: systolic/diastolic: <120 and <80 mm hg
|prehypertension: systolic/diastolic: 120~135 or 80~90 mm hg
|hypertension: systolic/diastolic: >140 or >90 mm hg
||stage 1: 140~160 or 90~100mm hg
||stage 2: 160~179 or 100~109 mm hg
||stage 3: >180 or >110 mm hg
參見:血壓量測(blood pressure measurement)
other
|blood pressure= cardiac output* peripheral vascular resistance= heart rate* stroke volume* peripheral vascular resistance
classification
|primary hypertension(原發性高血壓): Unknown causes, may be associated with genetic, diet, environment, stress-related
||Excess renal sodium retention
||Over activity of sympathetic nervous system
||Renin angiotensin excess
||Hyperinsulinemia: due to insulin resistance(胰島素抵抗)
||Alterations in vascular endothelium
|secondary hypertension(次發性高血壓)
||Renal: These account for over 80% of the cases of secondary
hypertension. The common causes are diabetic nephropathy, chronic
glomerulonephritis, adult polycystic disease, chronic tubulointerstitial
nephritis, and Renovascular hypertension(腎血管性高血壓)
||Endocrinal: These include
|||Hyperaldosteronism(醛固酮過多)=Conn syndrome
|||adrenal hyperplasia
|||acromegaly(肢端肥大症)
|||Pheochromocytoma(嗜鉻細胞瘤)
|||hypercortisolism(皮質醇過多)=Cushing’s Syndrome(庫欣氏症)
||Drugs
|||oral contraceptive: estrogen
|||非類固醇抗發炎藥(Non-Steroidal Anti-inflammatory Drugs)
|||MAO inhibitor with tyramine food
||Pregnancy-induced hypertension
||coarctation of the aorta, CoA(主動脈窄縮)
||vasculitis

資料來源:zuniv
檢查/準則(examination/criteria)
#Renovascular hypertension(腎血管性高血壓): Abdominal bruit especially with a diastolic component
治療(treatment)
$primary hypertension: Symptomatic treatment
$secondary hypertension: Curative treatment for the reasons
$Antihypertensive drugs should prevent ischemic cerebral stroke

資料來源:蘇丹卡布斯大學
other treatment classificaiton
$Nonpharmacological approaches
$$得舒飲食(DASH Diet)
$$low sodium chloride diet
$$weight reduction
$$exercise
$$cessation smoking
$$decrease in excessive alcohol consumption
$$psychological method
$$polyunsaturated fat intake
$Pharmacological approaches: if monotherapy is not effective, try to combine several kinds of drugs-->Hypotensive as soon as possible, do not reduce BP too low
$$STITCH-care shows that give twice kinds drug is better than one at first diagnosis
$low 2 mm hg-->7% reduction in risk of ischemic heart disease mortality, 10% reduction in risk of stroke mortality
鑑別診斷(Differential Diagnosis)

流行病學(Epidemiology)
+<50 y/o: Isolated diastolic hypertension
+50~60 y/o: Systoilic-diastolic hypertension
+>60 y/o: Isolated systolic hypertension
+secondary hypetension patients usually
++at age < 30 yrs ( Fibromuscular dysplasi) or > 55 (athelosclerotic renal artery stenosis)
++Episodic, headache and chest pain/palpitation
+Morbid obesity with history of snoring and daytime sleepiness (sleep disorders)
+Systolic BP is more risk than Diastolic BP

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