商品名(trade name) | |
藥理作用(Pharmacological Effects) | [structure is a sugar base, steroid and lactone [[C3、C14、C17 is functional group [[more OH group-->more excretion from renal [[[1 OH group: digotoxin, proscullaridin [[[2 OH group: digoxin, lanatoside C, deslanoside [[[5 OH group: g-strophanthin  資料來源：維基百科 type Pharmacological Effects [Direct action: activate Na+ dependent K+ channels and high intracellular Na+ concentration --> Ca2+-Na+ channel will hardly to transport Ca2+ from the cell to outside  資料來源：cvpharmacology [[Increased myocardial contraction intensity [[Slow AV conduction [[Enhanced vagal (parasympathetic) function, causing bradycardia [ECG [[QT interval shorten [[inversed T wave [[ST segment shorten [[PR interval increase: AV conduction delay [[QRS complex prolong |
用量與用法(Dosage and Usage) | half life ]Quabain: duration short, use IV injection ]digoxin: 40 hours, a little part via hepatic metabolism ]Digitoxin 168 hours, lots of part via hepatic metabolism |
適應症(Indications) | |
副作用(Side effect) | }digoxin has low therapeutic index-->carefully use }visual problems }fatigue }stupor }anorexia }nausea }vomiting toxicity: Digibind(digoxin antibody), KCl to relieve }bigeminy: normal sinus rhythm and a VPC }Ventricular Premature Contractions, VPCs(心室期外收縮) }Atrioventricular block(房室傳導阻滯) }Ventricular Tachycardia, VT(心室頻脈) }Ventricular Fibrillation,VF(心室顫動) }arrhythmia(心律不整): use antiarrhythmic agents |
禁忌/交互作用(Contraindications / interaction) | Contraindications }hypokalemia: reduce metabolism of Cardiac glycosides }Hypercalcemia(高血鈣症) }Atrioventricular block(房室傳導阻滯) patient }Wolff-Parkinson-White Syndrome, WPW syndrome }idiopathic hypertrophic subaortic stenosis, IHSS interaction ?antibiotics: due to antibiotics kill bacteria and cause Cardiac glycosides absorption increase ?Corticosteroids: cause hypokalemia ?Thiazide: cause hypokalemia ?Loop diuretics: cause hypokalemia ?quinidine: do not combine use, will reduce Cardiac glycosides excretion |
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