Wednesday, November 13, 2013

propranolol

商品名(trade name)

藥理作用(Pharmacological Effects)
[beta1 blocker and beta 2 blocker
[[c-AMP dependent Ca2+ current decreased
參見:cAMP二級信差(cAMP second messenger)
[[SA and AV node or ectopic automaticity decreased
參見:心肌動作電位(cardiac muscle action potential)
[[SA and AV node Vmax decreased
[[AV conduction decreased
[[ECG
[[[Prolong PR interval
[[[QT interval is variable
[[[do not effect QRS complex
用量與用法(Dosage and Usage)
usage
]Per os (though high 1st pass effect)
適應症(Indications)
{supraventricular arrhythmia: treat for catecholamine excessive
{Hyperthyroidism(甲狀腺機能亢進)/thyrotoxicosis(甲狀腺毒症)
{hypertension(高血壓) patients
{{heart failure
{{CHD: angina, post MI
{{Hyper-adrenergic tone
{{Under physician’s judgment
副作用(Side effect)
}bronchospasm: due to block beta2 receptor
參見:腎上腺性接受器(Adrenoceptors)
}heart failure
}heart block
}withdrawal syndrome: can not  suddenly stop drug
}bradycardia
}hard to find out hypoglycemia
}impotence
禁忌/交互作用(Contraindications / interaction)

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