hydralazine

商品名(trade name)
藥理作用(Pharmacological Effects)	[Direct relaxation of arteriolar smooth muscle [EDRF (NO) 參見：cGMP二級信差(cGMP second messenger) [Endothelium-Derived Hyperpolarizing Factor, EDHF: smooth muscle will be hyperpolarization-->hard to reach threshold [Stimulation of the sympathetic nervous system: negative feedback of hypotension [[Increase heart rate and contractility [[Increase plasma renin activity: combined use with beta adrenergic agonist to prevent renin [[Fluid retention: use diuretics
用量與用法(Dosage and Usage)	usage ]Orally ]High first pass effect ]Arterioles >> Venules ]Urine excretion
適應症(Indications)	{hypertension, pregnancy can use
副作用(Side effect)	}Angina pectoris: reactive tachycardia }Immunological reaction }}Lupus syndrome }}Hemolytic anemia }Inhibit methylation of DNA }I}nduce self-reactivity in T-cells
禁忌/交互作用(Contraindications / interaction)

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