Friday, November 15, 2013

Cardiac glycosides(強心配糖體)

商品名(trade name)

藥理作用(Pharmacological Effects)
[structure is a sugar base, steroid and lactone
[[C3、C14、C17 is functional group
[[more OH group-->more excretion from renal
[[[1 OH group: digotoxin, proscullaridin
[[[2 OH group: digoxin, lanatoside C, deslanoside
[[[5 OH group: g-strophanthin
資料來源:維基百科
type
[digoxin
[Digitoxin
[ouabain=strophanthin
[Lanatoside C
[proscillaridin
[rhodein
Pharmacological Effects
[Direct action: activate Na+ dependent K+ channels and high intracellular Na+ concentration --> Ca2+-Na+ channel will hardly to transport Ca2+ from the cell to outside
資料來源:cvpharmacology
[[Increased myocardial contraction intensity
[[Slow AV conduction
[[Enhanced vagal (parasympathetic) function, causing bradycardia
[ECG
[[QT interval shorten
[[inversed T wave
[[ST segment shorten
[[PR interval increase: AV conduction delay
[[QRS complex prolong
用量與用法(Dosage and Usage)
half life
]Quabain: duration short, use IV injection
]digoxin: 40 hours, a little part via hepatic metabolism
]Digitoxin 168 hours, lots of part via hepatic metabolism
適應症(Indications)
副作用(Side effect)
}digoxin has low therapeutic index-->carefully use
}visual problems
}fatigue
}stupor
}anorexia
}nausea
}vomiting
toxicity: Digibind(digoxin antibody), KCl to relieve
}bigeminy: normal sinus rhythm and a VPC
}Ventricular Premature Contractions, VPCs(心室期外收縮)
}Atrioventricular block(房室傳導阻滯)
}Ventricular Tachycardia, VT(心室頻脈)
}Ventricular Fibrillation,VF(心室顫動)
}arrhythmia(心律不整): use antiarrhythmic agents
禁忌/交互作用(Contraindications / interaction)
Contraindications
}hypokalemia: reduce metabolism of Cardiac glycosides
}Hypercalcemia(高血鈣症)
}Atrioventricular block(房室傳導阻滯) patient
}Wolff-Parkinson-White Syndrome, WPW syndrome
}idiopathic hypertrophic subaortic stenosis, IHSS
interaction
?antibiotics: due to antibiotics kill bacteria and cause Cardiac glycosides absorption increase
?Corticosteroids: cause hypokalemia
?Thiazide: cause hypokalemia
?Loop diuretics: cause hypokalemia
?quinidine: do not combine use, will reduce Cardiac glycosides excretion

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