adenosine

商品名(trade name)
藥理作用(Pharmacological Effects)	[Acts on A1 receptors on AV node through Gi protein 參見：G蛋白偶合受體(G-protein-couple receptors, GPCR) 參見：多巴胺接受器(Dopamine receptors) [[K+ efflux increase: activates ACh M2 recepotr  參見：蕈鹼類受器(Muscarinic receptor)與尼古丁受器(nicotinic receptor) [[Ca 2+ influx decrease (via ↓c-AMP) [[AV node automaticity, slow A-V conduction [Shorten atrial APD APD=action potential duration
用量與用法(Dosage and Usage)
適應症(Indications)	{IV bolus for acute termination {reentry supraventricular tachycardia: Paroxysmal supraventricular tachycardia, PSVT
副作用(Side effect)	}Transient asystole(<10 sec.) }chest fullness }dyspnea(呼吸困難)
禁忌/交互作用(Contraindications / interaction)	Contraindications ?Atrial Fibrillation, AF(心房顫動) ?Atrial Flutter(心房撲動) with Wolff-Parkinson-White Syndrome, WPW syndrome interaction ?Dipyridamole: Dipyridamole可以抑制adenosine在細胞外的回收，使的adenosine的濃度升高，胞外的adenosine會與細胞上的adenosine type2A receptor結合，再藉由Gs protein活化adenyl cyclase，使細胞內cAMP濃度上升，活化protein kinase，使ATP dependent的鉀離子通道打開，血管平滑肌過極化，造成肌肉的放鬆，達到血管擴張的效果 資料來源：asthma ?Theophylline: inhibition adenosine effect, due to Theophylline block A1 receptors ?caffeine: inhibition adenosine effect, due to Theophylline block A1 receptors

看更多see more：藥理學(pharmacology)HomeAny source