Monday, November 11, 2013

Bretylium

商品名(trade name)

藥理作用(Pharmacological Effects)
[Direct action: inhibit Ix1 receptor of Purkinje fibers and ventricle

資料來源:cvpharmacology
[Indirect action: decrease NE exocytosis
[ECG can see PR interval , QRS complex are not effected ,only  QT prolongs-->Prolong APD and Prolong ERP
[strong alpha blocker: lead to persistent hypotension
參見:腎上腺性接受器(Adrenoceptors)
APD=action potential duration
用量與用法(Dosage and Usage)
]IV only
Pharmacokinetic
]renal excretion and without hepatic metabolism
適應症(Indications)
{2nd choice for severe ventricular arrhythmia
副作用(Side effect)
}hypotension: due to strong alpha blocker
禁忌/交互作用(Contraindications / interaction)

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